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predisposing mutation

(PREE-dih-SPOH-zing myoo-TAY-shun)
A genetic alteration that increases an individual’s susceptibility or predisposition to a certain disease or disorder. When such a variant (or mutation) is inherited, development of symptoms is more likely, but not certain. Also called deleterious mutation, disease-causing mutation, pathogenic variant, and susceptibility gene mutation.
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