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NCI Dictionary of Genetics Terms

5 results found for: V

variable expressivity
(VAYR-ee-uh-bul ek-spreh-SIH-vih-tee)
Variation in the traits, signs, or symptoms that can occur in individuals with the same condition. When there is variable expressivity, the trait may vary in clinical expression from mild to severe.
variant
(VAYR-ee-unt)
An alteration in the most common DNA nucleotide sequence. The term variant can be used to describe an alteration that may be benign, pathogenic, or of unknown significance. The term variant is increasingly being used in place of the term mutation.
variant of uncertain significance
(VAYR-ee-unt … un-SER-tin sig-NIH-fih-kunts)
A variation in a genetic sequence for which the association with disease risk is unclear. Also called unclassified variant, variant of unknown significance, and VUS.
variant of unknown significance
(VAYR-ee-unt … UN-none sig-NIH-fih-kunts)
A variation in a genetic sequence for which the association with disease risk is unclear. Also called unclassified variant, variant of uncertain significance, and VUS.
VUS
A variation in a genetic sequence for which the association with disease risk is unclear. Also called unclassified variant, variant of uncertain significance, and variant of unknown significance.