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NCI Dictionary of Genetics Terms

3 results found for: U

unaffected individual
(UN-uh-FEK-ted in-dih-VIH-joo-wul)
In genetics, describes an individual who does not have a particular phenotypic trait or disease.
unclassified variant
(un-KLA-sih-fide VAYR-ee-unt)
A variation in a genetic sequence for which the association with disease risk is unclear. Also called variant of uncertain significance, variant of unknown significance, and VUS.
uninformative result
(UN-in-FOR-muh-tiv reh-ZULT)
A negative test result in an individual where a clearly deleterious mutation has not been found in any family members. The genetic risk status of such an individual must be interpreted in the context of his or her personal and family history. Also called inconclusive result and indeterminate result.