variant of unknown significanceListen to pronunciation(VAYR-ee-unt … UN-none sig-NIH-fih-kunts)A variation in a genetic sequence for which the association with disease risk is unclear. Also called unclassified variant, variant of uncertain significance, and VUS.Search NCI's Dictionary of Genetics TermsStarts withContainsBrowse:ABCDEFGHIJKLMNOPQRSTUVWXYZ#