Soft Tissue Sarcoma Research
Targeting the Accomplice: A Potential Treatment Approach for RhabdomyosarcomaPosted:
The fusion protein that drives the growth and survival of some rhabdomyosarcoma tumors relies on the KDM4B enzyme, researchers have found. Treating mice with a KDM4B-blocking drug and chemotherapy nearly eliminated rhabdomyosarcoma tumors with the fusion protein.
Pazopanib Shows Promise for Children, Adults with Soft Tissue SarcomasPosted:
For children and adults with advanced soft tissue sarcoma, adding pazopanib (Votrient) to chemotherapy and radiation before surgery may be a promising treatment option, early results from a clinical trial suggest.
Trial Should Change Care for AIDS-Related Kaposi Sarcoma in Sub-Saharan AfricaPosted:
For people with advanced AIDS-related Kaposi sarcoma in sub-Saharan Africa, results from a large clinical trial are expected to change treatment. In the trial, paclitaxel greatly improved outcomes compared with treatments typically used in the region.
Avapritinib Approved to Treat GIST with a Rare Gene AlterationPosted:
Avapritinib (Ayvakit) has been approved for adults with gastrointestinal stromal tumors (GIST) whose tumors have an alteration in a portion of the PDGFRA gene called exon 18. The approval applies to those whose tumors cannot be removed with surgery or have spread.
Epigenetic Changes Pinpointed as the Cause of Some GISTsPosted:
Scientists may have pinpointed the cause of some gastrointestinal stromal tumors (GISTs), a rare cancer, according to a new NCI-funded study. However, the culprit isn’t a harmful genetic mutation, but another type of genetic change, what are called epigenetic alterations.
Immunotherapy Effective in Alveolar Soft Part SarcomaPosted:
People with advanced alveolar soft part sarcoma (ASPS), a rare cancer, appear to benefit from a type of immunotherapy called an immune checkpoint inhibitor, according to results from a small clinical trial.
NIH-funded study shows sorafenib improves progression-free survival for patients with rare sarcomasPosted:
Interim results from a clinical trial for patients with desmoid tumors or aggressive fibromatosis (DT/DF) show that the drug sorafenib tosylate (Nexavar) extended progression-free survival compared with a placebo.
New Targeted Therapies Show Promise for Treating Advanced GISTPosted:
Two new targeted therapies have shown promise in patients with gastrointestinal stromal tumors (GIST) that have developed resistance to standard therapies.
Olaratumab Approved to Treat Advanced Soft Tissue SarcomaPosted:
The Food and Drug Administration (FDA) has granted accelerated approval to olaratumab (Lartruvo®) for the treatment of some patients with soft tissue sarcoma.
FDA Approves Eribulin Mesylate for Advanced LiposarcomaPosted:
The FDA has approved eribulin mesylate for patients with liposarcoma whose cancers are advanced or cannot be removed by surgery and are no longer responding to anthracycline-based chemotherapy.
FDA Approves Trabectedin to Treat Two Types of Soft Tissue SarcomaPosted:
The FDA has approved trabectedin for patients with advanced liposarcoma and leiomyosarcoma whose cancer has progressed after prior treatment.
In Mice, New Drug Conjugate Suggests Promise for Hard-to-Treat Pediatric CancersPosted:
Findings from a study in mice suggests that a new type of drug conjugate may have potential as a treatment for two cancers that are often diagnosed in children.