Soft Tissue Sarcoma Research
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Pazopanib Shows Promise for Children, Adults with Soft Tissue SarcomasPosted:
For children and adults with advanced soft tissue sarcoma, adding pazopanib (Votrient) to chemotherapy and radiation before surgery may be a promising treatment option, early results from a clinical trial suggest.
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Trial Should Change Care for AIDS-Related Kaposi Sarcoma in Sub-Saharan AfricaPosted:
For people with advanced AIDS-related Kaposi sarcoma in sub-Saharan Africa, results from a large clinical trial are expected to change treatment. In the trial, paclitaxel greatly improved outcomes compared with treatments typically used in the region.
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Avapritinib Approved to Treat GIST with a Rare Gene AlterationPosted:
Avapritinib (Ayvakit) has been approved for adults with gastrointestinal stromal tumors (GIST) whose tumors have an alteration in a portion of the PDGFRA gene called exon 18. The approval applies to those whose tumors cannot be removed with surgery or have spread.
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Epigenetic Changes Pinpointed as the Cause of Some GISTsPosted:
Scientists may have pinpointed the cause of some gastrointestinal stromal tumors (GISTs), a rare cancer, according to a new NCI-funded study. However, the culprit isn’t a harmful genetic mutation, but another type of genetic change, what are called epigenetic alterations.
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Immunotherapy Effective in Alveolar Soft Part SarcomaPosted:
People with advanced alveolar soft part sarcoma (ASPS), a rare cancer, appear to benefit from a type of immunotherapy called an immune checkpoint inhibitor, according to results from a small clinical trial.
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NIH-funded study shows sorafenib improves progression-free survival for patients with rare sarcomasPosted:
Interim results from a clinical trial for patients with desmoid tumors or aggressive fibromatosis (DT/DF) show that the drug sorafenib tosylate (Nexavar) extended progression-free survival compared with a placebo.
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New Targeted Therapies Show Promise for Treating Advanced GISTPosted:
Two new targeted therapies have shown promise in patients with gastrointestinal stromal tumors (GIST) that have developed resistance to standard therapies.
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Olaratumab Approved to Treat Advanced Soft Tissue SarcomaPosted:
The Food and Drug Administration (FDA) has granted accelerated approval to olaratumab (Lartruvo®) for the treatment of some patients with soft tissue sarcoma.
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FDA Approves Eribulin Mesylate for Advanced LiposarcomaPosted:
The FDA has approved eribulin mesylate for patients with liposarcoma whose cancers are advanced or cannot be removed by surgery and are no longer responding to anthracycline-based chemotherapy.
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FDA Approves Trabectedin to Treat Two Types of Soft Tissue SarcomaPosted:
The FDA has approved trabectedin for patients with advanced liposarcoma and leiomyosarcoma whose cancer has progressed after prior treatment.
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In Mice, New Drug Conjugate Suggests Promise for Hard-to-Treat Pediatric CancersPosted:
Findings from a study in mice suggests that a new type of drug conjugate may have potential as a treatment for two cancers that are often diagnosed in children.