Soft Tissue Sarcoma Research
New Targeted Therapies Show Promise for Treating Advanced GISTPosted: December 21, 2016
Two new targeted therapies have shown promise in patients with gastrointestinal stromal tumors (GIST) that have developed resistance to standard therapies.
Olaratumab Approved to Treat Advanced Soft Tissue SarcomaPosted: November 2, 2016
The Food and Drug Administration (FDA) has granted accelerated approval to olaratumab (Lartruvo®) for the treatment of some patients with soft tissue sarcoma.
FDA Approves Eribulin Mesylate for Advanced LiposarcomaPosted: February 11, 2016
The FDA has approved eribulin mesylate for patients with liposarcoma whose cancers are advanced or cannot be removed by surgery and are no longer responding to anthracycline-based chemotherapy.
FDA Approves Trabectedin to Treat Two Types of Soft Tissue SarcomaPosted: December 4, 2015
The FDA has approved trabectedin for patients with advanced liposarcoma and leiomyosarcoma whose cancer has progressed after prior treatment.
In Mice, New Drug Conjugate Suggests Promise for Hard-to-Treat Pediatric CancersPosted: June 30, 2015
Findings from a study in mice suggests that a new type of drug conjugate may have potential as a treatment for two cancers that are often diagnosed in children.
A key molecular defect in a childhood gastrointestinal tumor may have important diagnostic implicationsPosted: December 24, 2014
NCI scientists have identified a key molecular defect in a tumor in children known as gastrointestinal stromal tumor, or GIST, that may have important diagnostic implications.
NIH scientists map genetic changes that drive tumors in a common pediatric soft-tissue cancerPosted: January 23, 2014
Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease.
Experimental drug beneficial in NIH trial to treat a rare sarcomaPosted: May 2, 2013
Patients with advanced alveolar soft part sarcoma (ASPS), a rare cancer, achieved some control of their disease using an experimental anti-cancer drug called cediranib. The results from this largest clinical trial on ASPS to date were published in the Journal of Clinical Oncology
New Targeted Treatment May Slow Disease in Patients with Advanced GISTPosted: December 11, 2012
A new oral drug, regorafenib (Stivarga®), may delay the progression of advanced gastrointestinal stromal tumors (GIST) that are resistant to treatment, according to results from an international clinical trial published November 22, 2012, in The Lancet.
Drug that blocks blood vessel growth may be beneficial in treating AIDS-related Kaposi’s sarcomaPosted: March 20, 2012
Patients with an AIDS-associated cancer, Kaposi's sarcoma (KS), showed improvement after receiving the combination of bevacizumab, a cancer drug that blocks the growth of new blood vessels, and highly active antiretroviral therapy (HAART).
Combination Therapy for Advanced Kaposi SarcomaPosted: November 16, 2010
In this clinical trial, adult patients with any form of advanced Kaposi sarcoma will be treated with liposomal doxorubicin and bevacizumab every 3 weeks for a maximum of six treatments. Patients who respond to this therapy or have stable disease will receive bevacizumab alone every 3 weeks for a maximum of 11 treatments.
Cediranib to Treat Alveolar Soft Part SarcomaPosted: August 10, 2010
In this trial, patients with metastatic alveolar soft part sarcoma will be treated with cediranib by mouth once a day in 28-day cycles until disease progression or unacceptable toxicity.