This page contains brief information about cabozantinib-s-malate (Cabometyx/Cometriq) and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.
FDA label information for this drug is available at DailyMed.
Use in Cancer
Cabozantinib-s-malate is approved to treat:
- Differentiated thyroid cancer that has spread. It is used in adults and children aged 12 years and older who cannot receive radioactive iodine and whose cancer got worse after VEGF receptor-targeted therapy. This use is approved for the Cabometyx brand of cabozantinib-s-malate.
- Hepatocellular carcinoma (a type of liver cancer). It is used in patients who have already been treated with sorafenib. This use is approved for the Cabometyx brand of cabozantinib-s-malate.
- Medullary thyroid cancer that has gotten worse and has metastasized (spread to other parts of the body). This use is approved for the Cometriq brand of cabozantinib-s-malate.
- Renal cell carcinoma (a type of kidney cancer) that is advanced. It is either used with nivolumab as the first therapy or alone. This use is approved for the Cabometyx brand of cabozantinib-s-malate.
Cabozantinib-s-malate is also being studied in the treatment of other types of cancer.
More About Cabozantinib-S-Malate
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
MedlinePlus Information on Cabozantinib-S-Malate (for thyroid cancer) and Cabozantinib-S-Malate (for renal cell carcinoma) - Lay language summaries of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Research Results and Related Resources
Targeted Therapy Cabozantinib Slows Progression of Rare Kidney Cancer
Clinical Trials Accepting Patients
Find Clinical Trials for Cabozantinib S-malate - Check for trials from NCI's list of cancer clinical trials now accepting patients.