Datopotamab Deruxtecan-dlnk
Datopotamab deruxtecan-dlnk is a type of targeted therapy drug called an antibody–drug conjugate. It consists of a monoclonal antibody linked to a toxic drug called deruxtecan that binds to a protein on the surface of some cancer cells. The linked drug enters these cancer cells and blocks an enzyme called topoisomerase I. This damages the DNA of the cancer cells and kills them.
FDA label information for this drug is available at DailyMed.
Use in Cancer
Datopotamab deruxtecan-dlnk is approved to treat:
- Breast cancer that is hormone receptor positive (HR+) and HER2 negative (HER2-). It is used in adults who have received hormone therapy and chemotherapy for cancer that has spread or cannot be removed by surgery.
Datopotamab deruxtecan-dlnk is also being studied in the treatment of other types of cancer.
More About Datopotamab Deruxtecan-dlnk
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
MedlinePlus Information on Datopotamab Deruxtecan-dlnk - A lay language summary of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Research Results and Related Resources
Targeted Therapy to Treat Cancer
Clinical Trials Accepting Patients
Find Clinical Trials for Datopotamab Deruxtecan-dlnk - Check for trials from NCI's list of cancer clinical trials now accepting patients.