Durvalumab
This page contains brief information about durvalumab and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.
FDA label information for this drug is available at DailyMed.
Use in Cancer
Durvalumab is approved to treat adults with:
- bladder cancer that has spread to the muscle. It is used with gemcitabine hydrochloride and cisplatin before surgery to remove the bladder and then alone after surgery.
- biliary tract cancer, including cholangiocarcinoma and gallbladder cancer, that has spread. It is used with gemcitabine hydrochloride and cisplatin.
- endometrial cancer that is mismatch repair deficient (dMMR). It is used with carboplatin and paclitaxel and then alone in patients with cancer that has spread or has come back.
- hepatocellular carcinoma (a type of liver cancer) that cannot be removed by surgery. It is used with tremelimumab-actl.
- non-small cell lung cancer (NSCLC). It is used:
- with platinum-based chemotherapy before surgery and then alone after surgery in patients with cancer that can be removed by surgery and does not have an abnormal EGFR gene or ALK gene
- alone in patients with stage III cancer that cannot be removed by surgery but has not worsened after platinum-based chemotherapy and radiation therapy
- with tremelimumab-actl and platinum-based chemotherapy in patients with cancer that has spread to other parts of the body and does not have an abnormal EGFR gene or ALK gene
- small cell lung cancer. It is used:
- alone in patients with limited-stage cancer that did not get worse after platinum-based chemotherapy given at the same time as radiation therapy
- with etoposide phosphate and either carboplatin or cisplatin as the first treatment in patients with extensive-stage cancer
Durvalumab is also being studied in the treatment of other types of cancer.
More About Durvalumab
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
MedlinePlus Information on Durvalumab - A lay language summary of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Research Results and Related Resources
Cetuximab Outperforms Durvalumab for Head and Neck Cancer When Cisplatin Isn’t an Option
More Immunotherapy Options Approved for Treating Endometrial Cancer
Durvalumab Extends Lives of People with Early-Stage Small Cell Lung Cancer
Study Identifies a Potential Cause of Immunotherapy’s Heart-Related Side Effects
Targeted Therapy to Treat Cancer
Study Details Long-Term Side Effects of Immune Checkpoint Inhibitors
Clinical Trials Accepting Patients
Find Clinical Trials for Durvalumab - Check for trials from NCI's list of cancer clinical trials now accepting patients.