This page contains brief information about entrectinib and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.
Use in Cancer
Entrectinib is approved to treat:
- Non-small cell lung cancer that is ROS1 positive. It is used in adults whose cancer has metastasized (spread to other parts of the body).
- Solid tumors that have an NTRK gene fusion without a drug-resistance mutation in certain TRK proteins. It is used in adults and in children aged 12 years or older whose cancer has metastasized or cannot be removed by surgery and has gotten worse after other treatment or cannot be treated with other therapies.¹
¹This use is approved under FDA’s Accelerated Approval Program. As a condition of approval, confirmatory trial(s) must show that entrectinib provides a clinical benefit in these patients.
Entrectinib is also being studied in the treatment of other types of cancer.
More About Entrectinib
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
Research Results and Related Resources
Clinical Trials Accepting Patients
Find Clinical Trials for Entrectinib - Check for trials from NCI's list of cancer clinical trials now accepting patients.