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Ivosidenib

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 (I-voh-SIH-deh-nib )

Ivosidenib works by blocking an abnormal enzyme that some cancer cells with specific changes in the IDH-1 gene make. Blocking the abnormal enzyme may make cancer cells differentiate to become more like normal cells and grow more slowly. Ivosidenib is a type of targeted therapy drug called an enzyme inhibitor. It is a small-molecule drug (a drug that can enter cells easily).

US Brand Name(s)
Tibsovo
FDA Approved
Yes

FDA label information for this drug is available at DailyMed.

Use in Cancer

Ivosidenib is approved to treat adults whose cancer has a certain mutation in the IDH1 gene, including:

Ivosidenib is also being studied in the treatment of other types of cancer.

More About Ivosidenib

Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.

MedlinePlus Information on Ivosidenib - A lay language summary of important information about this drug that may include the following:

  • warnings about this drug,
  • what this drug is used for and how it is used,
  • what you should tell your doctor before using this drug,
  • what you should know about this drug before using it,
  • other drugs that may interact with this drug, and
  • possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Research Results and Related Resources

Targeted Therapy to Treat Cancer

Ivosidenib with Chemotherapy New Option for Some People with AML

Clinical Trials Accepting Patients

Find Clinical Trials for Ivosidenib - Check for trials from NCI's list of cancer clinical trials now accepting patients.

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