Topotecan hydrochloride is a chemotherapy drug that damages the DNA of cancer cells and other rapidly growing cells, causing them to die.
Use in Cancer
Topotecan hydrochloride is approved to be used alone or with other drugs to treat:
- Cervical cancer that is metastatic, has recurred (come back), or cannot be cured with other therapy. It is used with cisplatin.
- Ovarian cancer that is metastatic. It is used alone in patients whose cancer got worse during or after other chemotherapy.
- Small cell lung cancer that is platinum sensitive. It is used alone in patients whose cancer got worse after first-line chemotherapy.
Topotecan hydrochloride is also being studied in the treatment of other types of cancer.
More About Topotecan Hydrochloride
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
MedlinePlus Information on Topotecan Hydrochloride - A lay language summary of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Research Results and Related Resources
Clinical Trials Accepting Patients
Find Clinical Trials for Topotecan Hydrochloride - Check for trials from NCI's list of cancer clinical trials now accepting patients.