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Trifluridine and Tipiracil Hydrochloride

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 (try-FLOOR-ih-deen … ty-PEER-uh-sil HY-droh-KLOR-ide)

This chemotherapy combination contains the drugs trifluridine and tipiracil hydrochloride. Trifluridine enters cells and gets incorporated into the DNA, which keeps it from being copied. This stops cells from dividing. Tipiracil hydrochloride prevents trifluridine from being broken down in the body so it can kill more cancer cells.

US Brand Name(s)
FDA Approved

FDA label information for this drug is available at DailyMed.

Use in Cancer

Trifluridine and tipiracil hydrochloride is approved to treat adults with:

Trifluridine and tipiracil hydrochloride is also being studied in the treatment of other types of cancer.

More About Trifluridine and Tipiracil Hydrochloride

Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.

MedlinePlus Information on Trifluridine and Tipiracil Hydrochloride - A lay language summary of important information about this drug that may include the following:

  • warnings about this drug,
  • what this drug is used for and how it is used,
  • what you should tell your doctor before using this drug,
  • what you should know about this drug before using it,
  • other drugs that may interact with this drug, and
  • possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Research Results and Related Resources

Drug Combination May Have Potential for Cancers with TP53 Mutations

Drug Regimen Boosts Survival of People with Advanced Colorectal Cancer

Targeted Therapy to Treat Cancer

Clinical Trials Accepting Patients

Find Clinical Trials for Trifluridine And Tipiracil Hydrochloride - Check for trials from NCI's list of cancer clinical trials now accepting patients.

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