Trifluridine and Tipiracil Hydrochloride
This page contains brief information about the combination of trifluridine and tipiracil hydrochloride and a collection of links to more information about the use of this combination drug, research results, and ongoing clinical trials.
Use in Cancer
Trifluridine and tipiracil hydrochloride is approved to treat:
- Colorectal cancer that has metastasized (spread to other parts of the body). It is used in adults who have already been treated with a fluoropyrimidine, oxaliplatin, irinotecan hydrochloride, and a VEGF inhibitor. Patients whose cancer has the wild-type KRAS gene should have also received an EGFR inhibitor.
- Stomach adenocarcinoma or gastroesophageal junction adenocarcinoma (a rare type of esophageal cancer) that has metastasized. It is used in adults who have already received at least two treatments with a fluoropyrimidine and platinum chemotherapy and either a taxane or irinotecan and, in some cases, HER2/neu-targeted therapy.
Trifluridine and tipiracil hydrochloride is also being studied in the treatment of other types of cancer.
More About Trifluridine and Tipiracil Hydrochloride
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
MedlinePlus Information on Trifluridine and Tipiracil Hydrochloride - A lay language summary of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible side effects.
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Research Results and Related Resources
Clinical Trials Accepting Patients
Find Clinical Trials for Trifluridine And Tipiracil Hydrochloride - Check for trials from NCI's list of cancer clinical trials now accepting patients.