CCG Updates and Insights
Featuring current topics in cancer genomics research and news and updates from CCG.
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Interpreting Variants, Cancer Immunology Screens, and Insights Into Burkitt Lymphoma Biology: Latest OCG e-NewsletterThe latest edition of the Office of Cancer Genomics (OCG) e-Newsletter includes discussions from researchers on recent advances in cancer genomics, updates on some of our programs, and personal accounts on finding new ways to support cancer research.
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Low-Coverage Whole Genome Sequencing: Learning From Less DataLow-coverage whole-genome sequencing is a recent trend to sequence samples to a very low depth of coverage, often less than 1X. Researchers from very different fields (genetics and cancer diagnostics) are developing computational methods to learn useful information from the limited amount of data.
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CCG at AACR 2019Presentations and other activities with NCI's Center for Cancer Genomics (CCG) at AACR 2019, March 29 - April 3
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Beat AML 1.0: A Collaborative Program for Functional Genomic Data IntegrationThe Beat AML project integrates molecular, drug response, and clinical data for progress towards individualized therapies for acute myeloid leukemia patients. Dr. Jeffrey Tyner from Oregon Health and Science University describes the collaborative effort.
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Brain Tumors Through the Single-Cell RNA Sequencing Lens: Researcher Interview with Mario SuvàBrain cancers are notoriously hard to study, model, and treat. Dr. Mario Suvà speaks about how single-cell RNA sequencing is helping researchers gain clarity on the origins, development, and response to treatment for these cancers.
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Meticulous Reconstructions of Tumor Origins With Single-Cell DNA Sequencing: Researcher Interview with Nicholas NavinDr. Nicholas Navin talks about single-cell DNA sequencing and his research, considerations for working in the single-cell sequencing space, and what’s next for his lab.
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ATAC-seq on TCGA: Insights Into the Noncoding Region in Primary CancersResearchers used ATAC-seq to profile the chromatin accessibility of 410 TCGA samples representing 23 primary cancers. The study uncovered a vast number of novel DNA regulatory elements and their potential roles in cancer development, prognosis, and response to therapy.
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Getting to Know the Complexities of Cancer: A 2018 TCGA Symposium PreviewAt the 2018 Cell Symposium, TCGA Legacy: Multi-Omic Studies in Cancer, cancer genomics experts will discuss the latest research in molecularly characterizing cancer, classifying the disease, and the development of targeted therapy. A preview of how some researchers are starting to understand the complex and dynamic aspects of cancer.
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Finding Pediatric Cancer Genomic Data through PGDIThe Pediatric Genomic Data Inventory (PGDI), developed by the Office of Cancer Genomics (OCG), is a new public resource informing researchers how and where to access globally generated pediatric cancer genomic datasets. Connecting researchers with data and fostering collaborations is key to furthering our understanding of childhood cancers.
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From Ignoring Features to Machine Learning Features: Computational Biology Then and NowDr. John Weinstein discusses progress in computational biology over the 12-year span of TCGA. The field has expanded greatly, with researchers taking on more complex problems and trying different approaches.