Interpreting Variants, Cancer Immunology Screens, and Insights Into Burkitt Lymphoma Biology: Latest OCG e-Newsletter

May 13, 2019, by OCG Staff

Topics from the Office of Cancer Genomic's latest e-Newsletter.

Did you catch the latest edition of the Office of Cancer Genomics (OCG) e-Newsletter? Find discussions from researchers on recent advances in cancer genomics, updates on some of our programs, and personal accounts on finding new ways to support cancer research from staff in OCG, a member office of the Center for Cancer Genomics.

HCMI is developing next-generation cancer models including organoids and conditionally reprogrammed cells. Learn how to find models and associated data not only by cancer or tissue type, but also by clinical features such as histological grade, patient age, and tumor acquisition site with HCMI’s Searchable Catalog.

A key bottleneck in precision oncology is the lack of knowledge of the function of most cancer variants. Dr. Neal discusses several high-throughput functional screening methods to help translate cancer variants into disease mechanisms and actionable therapeutic hypotheses.

Burkitt Lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma with endemic (eBL) and sporadic (sBL) subtypes, and eBL is strongly associated with the presence of Epstein-Barr virus (EBV). Dr. Griner explains recent research on the role of EBV infection in BL tumorigenesis and what this might mean for different therapeutic strategies for the disease.

Dr. Simonds and colleagues explain mass cytometry—an antibody-based, cost-efficient method to measure the phenotypes of single cells. The workflow is a key component of immune-oncology research, where researchers are examining the immune infiltrates of tumors to better understand how the immune system responds to different tumor types and therapies.

Dr. Kyi, a new Health Communications Fellow at OCG, describes her neuroscience background and her quest to bring scientific facts and information to the public.


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