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Implementation Science in Low- and Middle-Income Countries

Doctor with clipboard talking with a indigenous Peruvian woman

Credit: D. Snyder

The Center for Global Health (CGH) supports implementation science for cancer prevention and control in low- and middle-income countries (LMICs) and low-resource settings.

Impact

A key challenge to reducing the global burden of cancer, particularly among people in LMICs and other populations experiencing disparities, is the poor implementation of cancer prevention and control strategies that are known to work. Implementation science is the study of how to integrate evidence-based practices into routine health settings to improve a population’s health. 

Key gaps currently exist between researchers, program implementers, and the populations they serve. Without bridging these gaps, the global impact of new scientific discoveries and evidence will be diminished. CGH invests in researching and addressing the challenges of implementing evidence-based interventions, tools, policies, and guidelines in low-resource settings.

Funded Research

CGH supports a growing portfolio of dissemination and implementation science for cancer control in LMICs through funding various opportunities.  

Funded Grants for Implementation Science

Grant NumberProject Leader(s)Collaborating InstitutionsTitleCountry
Global Implementation Science for Equitable Cancer Control (GlobalISE Cancer Control, U54 Clinical Trial Optional)
U54 CA284109  Maria Fernandez; Martin Lajous; Karla Unger-Saldaña  The University of Texas Health Science Center at Houston; Instituto Nacional de Salud Publica (INSP)-Mexico; Instituto Nacional de Cancerología (INCAN)-Mexico   LISTOS for Cancer Control - Leveraging Implementation Science To Optimize Strategies for Cancer Control  Mexico
U54 CA284110  Juliet Iwelunmor; Joseph Tucker; Oliver Ezechi   Washington University School of Medicine; The University of North Carolina at Chapel Hill; Nigerian Institute of Medical Research   US-Nigerian Cancer Control Center for Research on Implementation Science and Equity (C3-RISE)   Nigeria
U54 CA284036  Michael H. Chung;  Mohammed S. Ali Emory University  Enhanced BReast and cErvical cAncer screening in Kenya THROUGH   Kenya
U54 CA284030 Delivette Castor; Louise Kuhn; Nomonde Mbatani; Rakiya Saidu; Juanita Arendse; Rachel Shelton; Parisa Tehranifar   Columbia University Irving Medical Center; University of Cape Town; Columbia University Irving Medical Center   The Empilisweni Center for Women's Health - Advancing Implementation of Equitable Cervical Cancer Control  South Africa
Implementation Science for Cancer Control in People Living with HIV in Low- and Middle-Income Countries (U01 Clinical Trial Optional)
U01 CA275053 Rebecca G Nowak; Sylvia Adebajo University of Maryland Baltimore; Institute of Human Virology, Nigeria Integrated Model for the Prevention of Anal Cancer using Screen and Treat for HSIL (IMPACT) Nigeria
U01 CA275113 Lisa C Flowers; Oliver Ozechi; Olutosi Awolude; Laura Gaydos; Olabank Ogunsola Emory University; APIN Public Health Initiatives Ltd/Gte  The CHESS (Community, Home-based Education, Screening Services) Strategy to Increase Cervical Cancer Control Access for HIV-positive Women in Nigeria Nigeria
U01 CA275054 Sujha Subramanian; Michael Mbizvo; Catherine Mwaba Research Triangle Institute; Clinical and Radiation Oncology Society of Zambia (ZASCRO) Integrated Delivery of Cancer Control Interventions for Adolescents and Young Adults Living with HIV in Zambia Zambia
U01 CA275118 Gregory Aarons; Echezona Ezeanolue University of California, San Diego; University of Nigeria ACCESS: Accelerating Cervical Cancer Elimination Through the Integration of Screen-and-treat Services Nigeria

U01 CA275032 

Surbhi Grover; Katharine Rendle University of Pennsylvania;  University of Botswana Thibang Diphatlha: Testing Adaptive Strategies to Close the Gap from Cervical Cancer Diagnosis to Treatment in Botswana Botswana
U01 CA275048 Manhattan E Charurat; Seth Himelhoch; Bontle Mbongwe University of Maryland Baltimore; Botswana-UMSOM Health Initiative Botswana Smoking Abstinence Reinforcement Trial (BSMART) Botswana
U01 CA275033 Jean Marie Hunleth; Michelle Silver Washington University; Tropical Disease Research Centre Leveraging HIV Infrastructure to Implement Cervical Cancer Prevention: A Study to Integrate HPV Vaccination in Adolescent HIV Clinics in Zambia Zambia
U01 CA275129 Lifang Hou; Jane Holl; Mamoudou Maiga Northwestern University at Chicago; Jos University Teaching Hospital; University of Ibadan; Universite des Sciences, des Techniques et des TechnologiesWest Africa Self-Sampling HPV-based Cervical Cancer Control Program (WA-SS-HCCP) for WLWHA: Barriers, Challenges, and Needs Nigeria and Mali
U01 CA275120  Michael Chung  Emory University  ENHANcing CErvical cancer screening and treatment in women LIviNg with HIV in KenyA (ENHANCE LINKAge)  Kenya  
U01 CA275117  Gregory Kirk  Johns Hopkins University  Leveraging HIV care infrastructure for implementation of context-adapted liver cancer comprehensive control strategies in Uganda: The LC3 Study  Uganda
U01 CA294811  Thanh Bui  University of Oklahoma Health Sciences Center  Implementing Sustainable mobile health Technology to Optimize smoking cessation Program for Lao people with HIV (I-STOP)  Laos
U01 CA294674  Troy Moon  Tulane University of Louisiana  A hybrid type III effectiveness-implementation, pragmatic intervention trial for cervical cancer screen and treat in Mozambique  Mozambique
U01 CA294756  Corrina Moucheraud  New York University  Kupewa: Optimizing strategies to implement provider recommendation of HPV vaccination for adolescent girls and young women with HIV in Malawi  Malawi
U01 CA294799  Breanne Lott  Albert Einstein College of Medicine  Leveraging Project ECHO for improved cervical cancer screening in Ethiopia: An implementation study of integrated HPV self sampling in HIV care centers  Ethiopia
U01 CA294757  Matt Asare  Baylor University  The Impact of an Evidence-Based, Behavioral Cervical Cancer Screening Intervention among Women Living with HIV in Ghana (HOPE-inG): A Type 2 Hybrid Effectiveness Implementation Trial  Ghana
U01 CA275110 Rebecca Schnall  Columbia University  Implementation of Screen, Treat, and Triage for Women Living with HIV in La Romana (iSTAR)  Dominican Republic 

Additional Funded Research

How to Connect

CGH collaborates with NCI’s Division of Cancer Control and Population Sciences (DCCPS). For more information, see DCCPS’ Implementation Science team

For more information about implementation science at CGH, please contact Dr. Margarita Correa-Méndez and Dr. Randiak Alaro.

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