Documents from the Think Tank
Group photo of NCI SCOPE Think Tank participants.
Recordings from the Think Tank
Opening Remarks and Think Tank Objectives
- Welcoming Remarks and Charge to the Meeting - Drs. Sharmistha Ghosh-Janjigian and Dan Gallahan (NCI Division of Cancer Biology)
- Think Tank Objectives - Dr. Robert Eisenman (Fred Hutch)
- Focusing Attention on the Dosage, Dependencies, and Interactions of Oncogenic Proteins in Cancer Cells - Dr. Harold Varmus (Weill Cornell)
Session I: Oncogene Activities and the Acquisition of Malignant Phenotype
- Session I Aims - Dr. Dean Felsher (Stanford University) and Dr. Elizabeth Jaffee (Johns Hopkins University)
- MYC-Driven Oncogenesis: It Takes a Network - Dr. Robert Eisenman (Fred Hutch)
- Mechanisms of Tissue Tropism for Oncogenic RAS - Dr. Kevin Haigis (Dana-Farber Cancer Institute)
- Cooperative and Antagonistic Interactions between KRAS and HRAS in Skin and Lung Cancer Development - Dr. Allan Balmain (UCSF)
- Highlights and Summaries from Session I - Dr. Lukas Dow (Cornell University) and Dr. Sita Kugel (Fred Hutch)
Session II: Oncogenic Effects and Determinants of Cell Fate
- Session II Aims - Dr. Trever Bivona (UCSF) and Dr. Anirban Maitra (MD Anderson Cancer Center)
- MYC Cooperates with Cell of Origin to Dictate Tumor Plasticity - Dr. Trudy Oliver (Duke University)
- Metabolic Vulnerabilities of MYC-Driven Tumors: Opportunities and Challenges - Dr. Chi Van Dang (Johns Hopkins University)
- Regenerative Plasticity as an Oncogene-Induced Driver of Malignancy - Dr. Ronald Evans (Salk Institute)
- Investigating Amplified Oncogenes in the 3D Cancer Genome - Dr. Xiaoyang Zhang (University of Utah)
- Highlights and Summaries from Session II - Dr. Katja Lamia (Scripps Research Institute) and Dr. Ashani Weeraratna (Johns Hopkins University)
Session III: Oncogene Addiction - Possible Mechanisms and Potential Vulnerabilities
- Session III Aims - Dr. Robert Coffey (Vanderbilt University)
- Oncogene Addiction: Identifying Tumor Intrinsic Mechanisms That Can be Generally Exploited as Therapeutic Vulnerabilities - Dean Felsher (Stanford University)
- Dividing and Conquering Cancer by Understanding Oncogenic Dependencies - Dr. Lou Staudt (NCI Center for Cancer Research)
- Shifting Mechanisms of Escape from Oncogene Targeted Therapies - Dr. Charles Sawyers (MSKCC)
- Highlights and Summaries from Session III - Dr. Cory Abate-Shen (Columbia University) and Dr. Angelo De Marzo (Johns Hopkins University)
- Genetic Basis of Kidney Cancer: Oncogene/Oncogenic Pathways - Dr. Marston Linehan (NCI Center for Cancer Research)
Session IV: Leveraging Resources, Tools, and Models
- Session IV Aims - Dr. Kevin Haigis (Dana-Farber Cancer Institute) and Dr. Linghua Wang (MD Anderson Cancer Center)
- The Complexity of Oncogenes in the Germline - Dr. Stephen Chanock (NCI Division of Cancer Epidemiology and Genetics)
- Modeling Small-Cell Lung Cancer Development and Response to Therapy - Dr. Julien Sage (Stanford University)
- Computational Tools and Approaches for Oncogene Biology and Complexity - Dr. Linghua Wang (MD Anderson Cancer Center)
- Braking Bad: How Oncogenes Drive Ectopic Mutagenesis, Tumor Heterogeneity, and Therapy Resistance - Dr. Ping Mu (Yale University)
- Closing Remarks for the Think Tank - Drs. Sharmistha Ghosh-Janjigian and Rihab Yassin (NCI Division of Cancer Biology)
Social Media Related to the Think Tank
Social media posts related to the meeting can be found using #NCISCOPE24.
DCB Contact for the Think Tank
For additional information about the SCOPE Think Tank, please contact Sharmistha Ghosh-Janjigian.