Documents from the Workshop
Recordings from the Workshop
Introduction and Meeting Overview
- Opening Remarks – Shannon Hughes, Ph.D. & Dinah Singer, Ph.D. (NCI)
- Meeting Overview – Andrea Bild, Ph.D. (City of Hope)
Session 1: Innovative technologies and methods for translational medicine
- Multiscale modeling of clinical cancer progression – Sylvia Plevritis, Ph.D. (Stanford University)
- Forging the future of precision oncology with AI/ML and multimodal biomarkers - Aritro Nath (City of Hope)
- DNA Methylation: From Bench to Bedside – Beth Chang, Ph.D. (GRAIL, Inc.)
- Integrative genomic biomarkers for cancer clinical studies – Andrew Kung, M.D., Ph.D. (MSKCC)
- Challenges for selecting and scheduling combination therapeutics – Matthew Lazzara, Ph.D. (University of Virginia)
Session 2: Innovative clinical trial designs that implement systems biology models
- Innovative clinical trial designs for applying thoracic systems biology – Wade Iams, M.D. (Vanderbilt University)
- Utilizing systems biology models to improve outcomes of metastatic hormone receptor-positive breast cancer – Rachel Layman, M.D. (MD Anderson Cancer Center)
- An algorithm-driven strategy for a novel targeted therapy in breast cancer – Jose Silva, Ph.D. (Icahn School of Medicine)
- Integrating evolutionary mathematical models into clinical trials – Robert Gatenby, M.D. (Moffitt Cancer Center)
- Challenges and opportunities for biomarker intensive studies in oncology – Sunil Sharma, M.D., F.A.C.P., M.B.A. (TGen)
Session 3: Opportunities for technology advancement and collaboration across pharma, biotech, government, and academia (landscape analysis)
- Transforming Cancer Care with Foundation Medicine – Mia Levy, M.D., Ph.D. (Foundation Medicine)
- Addressing problems in drug discovery and early development with molecular profiling: opportunities for new technology and collaboration – Paul Rejto, Ph.D. (Pfizer)
- Emerging uses of cfDNA analyses in clinical trials & oncology translational research – Shiva Malek, Ph.D. (Novartis Institutes for BioMedical Research)
- AI-Enabled Precision Medicine is Here: Multi-Modal Data Collaborations to Advance Cancer Care and Drug Development – Calvin Chao, M.D. (Tempus)
- Clinical Research Opportunities in collaboration with the NCI Center for Cancer Research – James Gulley, M.D., Ph.D. (NCI)
Session 4: How to effectively match the speed of discovery and development with translation (implementation)
- Insights from I-SPY 2: A transformative Bayesian-driven platform trial – Anna Barker, Ph.D. (Ellison Institute)
- Key technologies to accelerate Biomarker-to-Bedside translation – Joris Van Dam, Ph.D. (Exact Sciences)
- Reaching Escape Velocity: Climb out of the valley of death & accelerate your product to market – Debbie Lin, Ph.D. (Caris Life Sciences)
- Public-private partnerships can accelerate path of drug development and clinical testing – Stacey Adam, Ph.D. (FNIH)
ARPA-H
- ARPA-H Overview - Tyler Best, Ph.D. (ARPA-H)
Session 5: Challenges and solutions for forward and reverse translational oncology
- Integrating research insights into clinical trials – Laura Heiser, Ph.D. (OHSU)
- Clinical Trial Designs: Looking Ahead - Sumithra Mandrekar, Ph.D. (Mayo Clinic)
- Technology and data foundations for accelerated therapeutic success, strong security and easy compliance - Kristy Cloyd-Warwick, Ph.D. (DNAnexus)
- Data Commons Lessons Learned and Future Directions - Jill Barnholtz-Sloan, Ph.D. (NCI)
Social Media Related to the Symposium
Social media posts related to the meeting can be found using #TranslationalSysBio.
DCB Contact for the Symposium
For additional information about the Translational Systems Biology Symposium, please contact Dr. Shannon Hughes.