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Epstein Barr Virus Associated Lymphoma Consortium (EALC)

Hematoxylin and eosin (HE) staining of the Epstein-Barr virus (EBV).

The Epstein Barr Virus Associated-Lymphoma Consortium (EALC) is advancing the understanding of the role of Epstein Barr virus (EBV) infection on Non-Hodgkin Lymphoma and/or Hodgkin disease development with or without an underlying HIV/AIDS infection. 

The goal of the consortium is to increase knowledge about how EBV promotes Non-Hodgkin Lymphoma and/or Hodgkin disease initiation, progression, and resulting conditions, as well as to provide insights into mechanistic differences in the relationship between EBV infection and lymphoma development in individuals with HIV infection and those without an underlying HIV infection.  

EALC News

EALC Project Highlight

 Dr. Blossom Damania and her team with the University of North Carolina at Chapel Hill EALC Project are investigating the role of FAM72A in EBV-driven lymphoma development and preclinically testing FAM72A inhibition as a potential therapy for EBV-associated lymphoma. 

DCB Contact for EALC

For additional information about the EALC, please contact Dr. Betsy Read-Connole.

Funded Projects

Institution Principal Investigator(s) Center Title
Duke University  Micah A. Luftig Defining and exploiting EBV-infected cell heterogeneity in non-Hodgkin lymphomas
John Hopkins University Richard F. Ambinder, Rena Xian Investigating the EBV methylome in PLWH: Discovery and development of novel EBV diagnostics in plasma and saliva
Stanford University Olivia Martinez, Sheri M. Krams Epstein Barr virus driven mechanisms of post transplant lymphoproliferative disease
University of Florida  Sumita Bhaduri-McIntosh, Michael McIntosh Synthetic lethal targeting of EBV-positive diffuse large B cell lymphomas in persons living with HIV
University of North Carolina at Chapel Hill Blossom A. Damania Targeting EBV-associated lymphomas
University of Wisconsin-Madison Eric C. Johannsen  Role of Epstein-Barr virus LMP2A protein in maintaining oncogenic IgM signaling in EBV+ B cell lymphomas
University of Wisconsin-Madison Shannon C. Kenney Roles of LMP1 and MYC in EBV-induced B-cell tumors
Washington University in St. Louis  Vikas R. Dharnidharka  Understanding the immune response changes to clinical interventions for Epstein-Barr virus infection prior to lymphoma development in children after organ transplants (UNEARTH)
Weill Cornell  Ethel Cesarman, Benjamin E. Gewurz, Lisa G. Roth

B cell determinants of EBV latency
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