The Clinical Trial Sequencing Project (CTSP) was launched to promote the use of genomics in NCI-sponsored clinical trials of the National Clinical Trials Network (NCTN).
CTSP’s goal was to elucidate the molecular basis of response and resistance to therapies.
Biospecimens collected from NCTN clinical trials underwent whole genome or whole exome sequencing in conjunction with transcriptome sequencing to identify genomic alterations important to research hypotheses.
CTSP Data
Genomic and anonymized clinical data from CTSP is available in the Genomic Data Commons (GDC).
Contact for CTSP
For additional information about the CTSP, please contact Dr. Liming Yang.
Past Projects
ECOG-ACRIN E2805 Trial of Renal Cell Carcinoma
This project involved the analysis of ~400 tissue samples from patients with high-risk, non-metastatic renal cell carcinoma (RCC) in an NCI-sponsored clinical trial, which tested the effectiveness of two inhibitors of vascular endothelial growth factor (VEGF).
Diffuse Large B Cell Lymphoma Trial
This project involved a comprehensive molecular analysis of tissue samples from patients with Diffuse Large B Cell Lymphoma (DLBCL) in a Phase III clinical trial, which tested the effectiveness of rituximab (an antibody that targets B cells for destruction) in combination with one of two different chemotherapy regimens.
The in-depth analysis of DLBCL samples from this trial aimed to reveal important mechanistic insights into DLBCL subtypes and predictors of tumor resistance.