A critical unmet need in the management of malignancies is the development of minimally invasive methods that predict whether a screen-detected lesion is indolent (i.e., requiring only careful monitoring) or progressive (requiring appropriate intervention).
DCB and the NCI Division of Cancer Prevention (DCP) supported the Molecular Characterization of Screen-Detected Lesions (MCL) consortium, which worked to comprehensively characterize cellular and molecular components of early lesions and identify features that distinguish indolent from aggressive/progressive lesions. Multi-disciplinary MCL teams (that were funded by RFA-CA-14-010 & RFA-CA-14-011) used enabling technologies to inform better predictions of the fate of precancers and early lesions.
MCL Highlight
Using histological, molecular, and immunological profiling approaches in a recent NPJ Breast Cancer study, Nachmanson et al. generated a breast precancer atlas showing the molecular and microenvironmental heterogeneity of ductal carcinoma in situ (DCIS).
Past Projects
| Institution | Principal Investigator(s) | Project Title |
|---|
| Baylor College of Medicine | Christopher Amos | Coordinating Center: Molecular and Cellular Findings of Screen-Detected Lesions |
| Johns Hopkins University | Kenneth Pienta,
Angelo De Marzo | Multidiciplinary Integrative Genomic Approach to Distinguish Lethal from Indolent Prostate Cancer in Men of Europena and African Ancestry |
| MD Anderson Cancer Center | Anirban Maitra | Imaging and Molecular Correlates of Progression in Cystic Neoplasms of the Pancreas |
| Stanford University | James Brooks | Stanford Molecular and Cellular Characterization Laboratory |
| University of California, Los Angeles | Steven Dubinett,
Denise Aberle,
Fenghai Duan,
Marc Lenburg | Integrated Molecular, Cellular, and Imaging Characterization of Screen-Detected Lung Cancer |
| University of California, San Francisco | Laura Esserman,
Alexander Borowsky | Elucidating the Molecular and Contextual Basis for IDLE Utralow Risk Lesions and the Tumor Immune Microenvironment of High Risk In Situ and Invasive Breast Cancers |
| University of Vermont & State Agricultural College | Janet Stein,
Brian Sprague,
Donald Weaver | Vermont Breast Cancer Molecular Characterization Laboratory |
| Vanderbilt University Medical Center | Pierre Massion,
Fabien Maldonado | Cellular, Molecular and Quantitative Imaging Analysis of Screening-Detected Lung Adenocarcinoma |
