Tumor Microenvironment Network Investigators
| Project Title | PI and Co-Investigators | Grantee Institution |
|---|---|---|
| Pancreatic Tumor Microenvironment Network (U54 CA163120) | Surinder Batra, Michael Hollingsworth, Keith Johnson, Rakesh Singh, Kay-Uwe Wagner | University of Nebraska Medical Center |
| Pancreatic Tumor Microenvironment Network (U54 CA163120) | Gabriele Bergers, Tracy McKnight, Anders Person, Joanna Phillips, Valerie Weaver, William Weiss | University of California, San Francisco |
| Biophysical and molecular dialogue of glioma cells and the brain microenvironment (U54 CA163155) | Mina Bissell Nancy Boudreau, Catherine Park | University of California-Lawrence Berkeley Lab |
| Bioengineering 3-D Models for Breast Cancer Therapy (U54 CA126552) | Lynda Chin/Andrew Futreal, Ron DePinho, Keith Flaherty, Gordon Freeman, Stephen Hodi, Arlene Sharpe, Jennifer Wargo | University of Texas - MD Anderson Cancer Center |
| Role of Tumor Stroma in Therapeutic Response and Resistance (U54 CA163125) | Michael Clarke, Pat Brown, Stephen Quake | Stanford University |
| Molecular and Functional Characterization of Colon Tumor Cancer Stem Cells and Stroma (U54 CA126524) |
John Condeelis, James Castracane | Albert Einstein College of Medicine |
| Novel Methods for Detecting Cell Interactions in the Tumor Microenvironment (U54 CA126511) | John Condeelis, Julio Aguirre-Ghiso, James Castracane, Patricia Keely, Ihor Lemischka, Vladislav Verkhusha | Albert Einstein College of Medicine |
| Tumor microenvironments determining migration, dissemination and dormancy (U54 CA163131) | Lisa Coussens, Heiko Daldrup-Link, Matthew Krummel, Laura Van't Veer | Oregon Health & Science University |
| Leukocyte Biomarkers for Predicting Human Breast Cancer Outcomes (U54 CA163123) | Yves Declerck, Shahab Asgharzadeh, Richard Jove, Robert Seeger, Hua Yu | Children's Hospital of Los Angeles |
| Center for Environment-Mediated Drug Resistance in Pediatric Cancer (U54 CA163117) | Eric Holland, Jason Huse, Joan Massague, Shahin Rafii | Fred Hutchinson Cancer Research Center |
| Role of the Perivascular Microenvironment in Primary and Metastatic Brain Tumors (U54 CA163167) | Eric Holland, Johanna Joyce, Joan Massague | Sloan-Kettering Institute of Cancer Research |
| Tumor Microenvironment Interactions in Brain Tumors (U54 CA126518) | Richard Hynes, Sangeeta Bhatia, Steven Carr, Karl Clauser, Tyler Jacks, Mikael Pittet, Andrea Richardson, Alice Shaw, Kenneth Tanabe, Robert Weinberg | Massachusetts Institute of Technology |
| Impact of Cellular and Extracellular Host Components on Tumor Progression (U54 CA163109) | Richard Hynes, Tyler Jacks, Mikael Pittet, Robert Weinberg, Ralph Weissleder | Massachusetts Institute of Technology |
| Tumor-Stroma Interactions in the Tumor Microenvironment (U54 CA126515) | Raghu Kalluri, Glenn Bubley, Pier Paolo Pandolfi, David Scadden | University of Texas - MD Anderson Cancer Center |
| Stromal Regulation of Bone Metastasis (U54 CA163191) | Lynn Matrisian, Neil Bhowmick, Richard Caprioli, Lynda Chin, John Gore, Simon Hayward, Harold Moses, Greg Mundy, John Quakenbush, Yu Shyr | Vanderbilt University |
| Paracrine TGF-Beta Signaling in Tumor Initiation and Progression (U54 CA126505) | Stephen Plymate, Judith Campisi, William Carter, Peter Nelson, Robert Vessella | University of Washington |
| Significance of Microenvironment for Prostate Cancer Initiation and Progression (U54 CA126540) | David Rowley, Gustavo Ayala, Michael Ittmann | Baylor College of Medicine |
| Mechanisms of Prostate Cancer Dormancy in the Bone Marrow Niche (U54 CA163124) | Russell Taichman, Arul Chinnaiyan, Kenneth Pienta, Yusuke Shiozawa | University of Michigan |
| Myofibroblasts in Gastrointestinal Cancers (U54 CA163111) | Timothy Wang, James Fox, Robert Schwabe, Benjamin Tycko | Columbia University Health Science |
| The Role of Inflammation and Stroma in Digestive Cancer (U54 CA126513) | Timothy Wang, William Blaner, Andrea Califano, Andreas Hielscher, Charles Powell, Robert Schwabe, Benjamin Tycko | Columbia University Health Science |
| GI Tract Dysbiosis and Breast Cancer (U01 CA164337) | Susan Erdman, Eric Alm, Timothy Wang | Massachusetts Institute of Technology |
| Molecular Determinants of Tumor Progression in A Steatolic Liver Microenvironment (U01 CA143072) | David Gorden, Lynn Matrisian, Oliver McIntyre, Harold Moses, Michael VanSaun | Vanderbilt University |
| Differential TGF-Beta Signaling in Bone Microenvironment: Impact on Tumor Growth (U01 CA143057) |
Theresa Guise, Neil Bhowmick, Khalid Mohammad | Indiana University at Indianapolis |
| Non-neoplastic cell types dictate gliomagenesis and response to therapy (U01 CA160882) | Dolores Hambardzumyan, David Gutmann, Eric Holland, Helmut Kettenmann | Emory University |
| Role of Fibroblasts, Myeloid Cells and Matrix in PDAC (U01 CA151925) | Raghu Kalluri, Harold Moses, Valerie Weaver | University of Texas - MD Anderson Cancer Center |
| Characterization and Functional Analysis of Breast Cancer Secreted Exosomes in Malignant Progression (U01 CA169538) | David Lyden, Mina Bissell, Hector Peinado-Selgas | Weill Medical College of Cornell University |
| Reactive Stroma and Tumor Associated Macrophages in Prostate Cancer Progression (U01 CA143055) | Kenneth Pienta, David Rowley | Johns Hopkins University |
| Myoepithelial cell differentiation defects in ductal carcinoma in situ (U01 CA143233) | Kornelia Polyak, Mina Bissell, Jeffrey Pollard | Dana-Farber Cancer Institute |
| Inflammation and the esophageal tumor microenvironment (U01 CA143056) | Anil Rustgi, Umar Mahmood, Timothy Wang | University of Pennsylvania |
| Influences of the Microenvironment on Cancer Stem Cells (U01 CA164188) | Hong WuOwen Witte, Peter Nelson | University of California Los Angeles |