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The Landscape of Post‐Translational Modifications in Tumor Biology Workshop

The Landscape of Post-Translational Modifications in Tumor Biology Workshop banner with post-translational modification structures overlaying an image of a tumor

To discuss the role of post-translational modifications (PTMs) in tumor biology, NCI held a virtual workshop on Sept. 22 – 23, 2022. The meeting brought together researchers in key and diverse areas of PTMs (including ubiquitination, phosphorylation, acetylation, methylation, and glycosylation) to discuss the current status of science, important advances, and challenges that may stand in the way of new directions and opportunities when attempting to unravel the complexities of tumor biology.

Experts in the field were invited to present their research and discuss how to better integrate these disparate – yet interconnected areas of PTM research as integral building blocks underlying tumor biology from bench to bedside.

Background for the Workshop

PTMs expand protein structure/function, enabling dynamic adaptation to cell-intrinsic and extrinsic stimuli. However, there are knowledge gaps in understanding how these modifications work in a coordinated way to drive or suppress tumorigenesis and response to cancer therapy.

Documents from the Workshop

Tweets about the workshop can be found using #NCIPTM22.

DCB Contacts for the Workshop

For additional information about the workshop, please contact Dr. Natalia Mercer, Dr. Ruibai Luo, or Dr. Wanping Xu. 

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