Alliance of Glycobiologists for Cancer Research

Representative image for the Alliance of Glycobiologists for Cancer Research

Credit: NCI Division of Cancer Prevention

Glycans are sugars that are linked together, which often form complex structures and are bound to proteins and lipids. These molecules are expressed on the surfaces of cells and mediate many biological processes. Recent evidence suggests that cancers display alterations in glycan structures, and glycan-based biomarkers represent a largely untapped area relevant to cancer detection and diagnosis.

This Alliance determined the biological mechanisms that alter glycosylation to promote cancer and developing glycan-based markers that can be used for the early detection of cancer.

The U01 research projects of the Alliance were funded by DCB and the NCI Division of Cancer Prevention through PAR-17-206 and PAR-17-207.

Biological Tumor Glycomics Laboratories

The five Biological Tumor Glycomics Laboratories of the Alliance advanced the understanding of the role of altered glycosylation and other modifications in carbohydrate structure in cancer. Researchers of the laboratories investigated the biology of modifications in carbohydrate structure that influence cellular transformation, cancer progression, and metastasis. Ultimately, the basic findings and glycobiological data aim to be the translated into clinical applications.

Translational Tumor Glycomics Laboratories

The five Translational Tumor Glycomics Laboratories of the Alliance discovered how structural changes in carbohydrates promote cancer progression and identified glycan-based abnormalities that can be used as biomarkers for early cancer detection. The most promising biomarker candidates will ultimately be tested in clinical validation studies.

Partnering Groups with the Alliance

Common Fund Glycoscience (CFG) Program - Offered many unique core resources that are specific to glycomics and CFG labs developed and shared numerous tools for glycoscience studies.
NCI's Early Detection Research Network (EDRN) - Promotes the clinical validation of cancer biomarkers for early detection and cancer risk.

Resources from the Alliance of Glycobiologists

Standard Operating Procedures

Alliance of Glycobiologists for Cancer Research Manual of Operations

Database Sources and Analysis Tools

Reagents

Glycan Array Experiments

Useful Websites

DCB Contact for the Alliance

For additional information about the Alliance of Glycobiologists for Cancer Research, please contact Dr. Natalia Mercer.

Past Projects

PAR-17-206: Translational Tumor Glycomics Laboratories

Institution	Principal Investigator(s)	Project Title
Florida International University	Karen L. Abbott	Glycomics Laboratory for the for the Development of Ovarian Cancer Biomarkers
Van Andel Research Institute	Brian B. Haab, Randy Brand	Subpopulations of Pancreatic Cancer Cells Defined by Glycan Markers
University of Michigan at Ann Arbor	David M. Lubman, Yehia Mechref	Screening of Glycan Markers in Serum for Early Detection of HCC in Different Etiologies of Disease
Medical University of South Carolina	Anand S. Mehta, Richard Drake, Amit Singal, Yujin Hoshida	Glycopathology of HCC: Identification of the Source Cells of Serum Fucosylation
Stanford University	Sharon Pitteri, Carolyn Bertozzi, James Brooks	Glycosylation and Immune Evasion in Urologic Tumors

PAR-17-207: Biological Tumor Glycomics Laboratories

Institution	Principal Investigator(s)	Project Title
University of Alabama at Birmingham	Susan L. Bellis, Lance Wells	Sialylation-dependent Mechanisms Driving Pancreatic Cancer Progression
Florida International University	Charles Dimitroff, Stuart Haslam	Analysis of Glycomic Regulators in Melanoma Progression
Drexel University	Mauricio Reginato, Lauren Ball	Role of O-GlcNAcome on Breast Cancer Initiating Cells
Florida International University	Robert Sackstein	Analysis of E-selectin Ligands of Human Acute Leukemia Cells and their Biology in Leukemogenesis
University of South Florida	Lianchun Wang, Houjian Cai	Heparan Sulfate in Prostate Cancer