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Cancer Immunoprevention Network (CIP-Net)

An image of T cells interacting with dendritic cells.

A dendritic cell (blue) showing T cells (red) what antigens to look for. This helps T cells find cancer cells and infected cells.

Credit: National Institute of Allergy and Infectious Diseases

An emerging scientific opportunity is the development of approaches that leverage the immune system to prevent cancers. Further, an NCI Board of Scientifc Advisors (BSA) Ad Hoc Working Group encouraged fostering “novel and innovative research designs….to expedite progress in precision prevention.”

The Cancer Immunoprevention Network (CIP-Net), supported by DCB and the NCI Division of Cancer Prevention, is advancing a deeper understanding of basic mechanisms of immunoprevention, promoting the discovery of novel immunoprevention strategies, and fostering a community of cancer immunoprevention researchers.

Additional details about the network can be found on NCI Division of Cancer Prevention webpages about CIP-Net. 
 

CIP-Net News

New grants for CIP-Net were awarded in Fall 2025.

Drs. Nicholas Arpaia and Tal Danino with the Columbia University CIP-Net Project are preclinically engineering probiotic bacteria for colorectal cancer immunoprevention and interception.

The Mayo Clinic Arizona CIP-Net Project, led by Drs. Peter Bergsagel and Marta Chesi, is developing preclinical models to study immunoprevention of multiple myeloma.

Drs. Isabelle Bedrosian, Anjana Bhardwaj, and Preethi Gunaratne with the MD Anderson Cancer Center CIP-Net Project are using genomics and bioinformatics approaches to develop an immunoprevention strategy for BRCA 1/2 associated breast cancer.

The University of Arizona CIP-Net Project, led by Drs. Sally Dickinson and Clara Curiel-Lewandrowski, is investigating new targets for topical immunoprevention approaches in non-melanoma skin cancer.

The Roswell Park CIP-Net Data Resource Coordinating Center (DRCC), led by Drs. Alan Hutson, Steven Lipkin, and Song Liu, is  supporting collaboration across the network, as well as the sharing of data and resources generated through the program. 

DCB Contact for CIP-Net

For additional information about CIP-Net, please contact Dr. Lillian Kuo.

Funded Projects

CIP-Net Research Projects (UG3/UH3)

InstitutionPrincipal Investigator(s)Project Title
Columbia University Health SciencesNicholas Arpaia, Tal DaninoEngineered probiotic bacteria for colorectal cancer immunoprevention and interception
Emory UniversityMadhav V. Dhodapkar, Richard A. Flavell, Noah. W. PalmTargeting microbial triggers of gammopathy for immunoprevention
Icahn School of Medicine at Mount SinaiNina Bhardwaj, Aimee L. Lucas, Robert M. SamsteinImmune determinants modulating cancer development in Lynch Syndrome
Massachusetts General HospitalShadmehr DemehriImmunosurveillance of breast glands with oncogenic germline mutations
Mayo Clinic ArizonaPeter L. Bergsagel, Marta ChesiPreclinical studies for the immunoprevention of multiple myeloma
MD Anderson Cancer CenterIsabelle Bedrosian, Anjana Bhardwaj, Preethi H. GunaratneChimeric RNA driven neopeptide vaccine for prevention of breast cancer in germline BRCA1/2 carriers
University of ArizonaSally E. Dickinson, Clara Curiel-LewandrowskiInvestigating novel targets for topical immunoprevention of keratinocytic skin cancer
University of Missouri-ColumbiaHaval Shirwan, Esma S. YolcuDeveloping a novel agonist of CD137 for cancer immunoprevention CIP-Net Coordinating Center

CIP-Net Resource Coordinating Center (U24)

InstitutionPrincipal Investigator(s)Project Title
Roswell Park Cancer CenterAlan D. Hutson, Steven M. Lipkin, Song LiuCancer Immunoprevention Network (CIP-Net) Resource Coordinating Center
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