PSRC News
Publication Highlights
Using single-cell RNA sequencing and patient-derived models, Carpenter et al. with the University of Michigan PSRC Project identified KRT17-high/CXCL8+ intermediary tumor cells with both classical and basal pancreatic cancer subtype features, which regulate myeloid cell infiltration in the pancreatic cancer microenvironment. In a Commentary about the study, Faraoni & McAllister discuss how this discovery “emerges as a promising strategy which may help in pancreatic cancer patients’ stratification and clinical decision making.”
Using tumor explant models, Hasselluhn et al. with the Columbia University PSRC Project identified a key mechanism of angiosuppression (i.e. inhibition of the formation of new blood vessels) in pancreatic cancer, a process that shapes the tumor microenvironment.
Researchers with the PSRC Coordinating Center and the University of Michigan PSRC Project discuss recent advances an challenges in pancreatic cancer research.
PSRC Digital Media
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DCB Contact for the PSRC
For additional information about PSRC, please contact Dr. Jeff Hildesheim.
Funded Projects
PSRC Research Projects (U01s)
Institution | Principal Investigator(s) | Center Title |
---|---|---|
Columbia University Health Sciences | Kenneth P. Olive, Gulam A. Manji | Elucidation and targeting of paracrine cascades in PDAC |
Dana-Farber Cancer Institute | William C Hahn, Andrew J. Aguirre, Stephanie Dougan | Stromal modulation of pancreatic malignant cell state and therapeutic sensitivity |
University of Illinois at Urbana-Champaign | Bumsoo Han, Melissa S. Fishel, Matthew J. Flick | Reprogramming PDAC stroma by targeting coagulation in the tumor microenvironment |
University of California, San Diego | Michael Karin, Andrew M. Lowy, Robert F. Schwabe | Regulation of PDAC metabolism and immunity by collagen and its cleavage products |
University of Michigan | Marina Pasca Di Magliano, Howard C. Crawford, Timothy L. Frankel, Costas A. Lyssiotis |
Fibroblast orchestration of the immune response in pancreatic cancer |
University of North Carolina, Chapel Hill | Jen Jen Yeh, Naim Ur Rashid, Susan Tsai | Integrating tumor and stroma to understand and predict treatment response |
PSRC Coordinating and Data Management Center (U24)
Institution | Principal Investigator(s) | Center Title |
---|---|---|
MD Anderson Cancer Center | Anirban Maitra, J. Jack Lee | PASSCODE (Pancreatic Adenocarcinoma Stromal Reprogramming Consortium Coordination, Data Management and Education) |