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2-methoxyestradiol

An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.

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Synonym:	2-ME 2-MeE2 2-MeOE2 2-methoxy estradiol
US brand name:	Panzem
Abbreviation:	2ME2
Chemical structure:	(17beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol
IND number:	62972
NSC code:	659853

2-methoxyestradiol

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