vandetanib
View Patient InformationAn orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.
| US brand name: | Caprelsa Zactima |
|---|---|
| Foreign brand name: | Lucivand |
| Code name: | AZD6474 ZD-6474 ZD6474 |