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3-deazauridine

A synthetic analogue of nucleoside uridine lacking a ring nitrogen in the 3-position. 3-deazauridine inhibits cytidine synthase, thereby reducing intracellular levels of cytidine and deoxycytidine and disrupting DNA and RNA synthesis. This agent may trigger apoptosis and enhance differentiation of neoplastic cells.
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Synonym:deazauridine
Chemical structure:2(1H)-pyridinone, 4-hydroxy-1-beta-D-ribofuranosyl
4-hydroxy-1-(beta-D-ribopentofuranosyl)-2-pyridone
IND number:12540
NSC code:126849
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