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trifluridine

A fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity.
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Synonym:triflorothymidine
Abbreviation:F3TdR
Chemical structure:2'-Deoxy-5-trifluoromethyluridine
IND number:3953
NSC code:75520
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