Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

dactinomycin

View Patient Information
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:actinomycin A IV
actinomycin C1
actinomycin D
actinomycin I1
actinomycin IV
actinomycin X 1
actinomycin-[thr-val-pro-sar-meval]
dactinomycine
meractinomycin
US brand name:Cosmegen
Foreign brand name:Lyovac Cosmegen
Abbreviation:DACT
Chemical structure:2-bis[cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search