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busulfan

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A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription.
Synonym:bussulfam
busulfanum
busulphan
glyzophrol
joacamine
methanesulfonic acid tetramethylene ester
myeleukon
myeloleukon
myelosan
mylecytan
sulfabutin
tetramethylene bis(methanesulfonate)
US brand name:Busulfex
Myleran
Foreign brand name:Busilvex
Mielucin
Misulban
Misulfan
Mitosan
Abbreviation:BUS
Code name:CB-2041
GT-41
WR-19508
Chemical structure:1,4-bis(methanesulfonoxy)butane
1,4-bitanediol dimethanesulfonate esters
1,4-butanediol dimethylsulfonate
1,4-di(methanesulfonyloxy)butane
1,4-di(methylsulfonyloxy)butane
NSC code:750
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