busulfan
View Patient InformationA synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription.
| Synonym: | bussulfam busulfanum busulphan glyzophrol joacamine methanesulfonic acid tetramethylene ester myeleukon myeloleukon myelosan mylecytan sulfabutin tetramethylene bis(methanesulfonate) |
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| US brand name: | Busulfex Myleran |
| Foreign brand name: | Busilvex Mielucin Misulban Misulfan Mitosan |
| Abbreviation: | BUS |
| Code name: | CB-2041 GT-41 WR-19508 |
| Chemical structure: | 1,4-bis(methanesulfonoxy)butane 1,4-bitanediol dimethanesulfonate esters 1,4-butanediol dimethylsulfonate 1,4-di(methanesulfonyloxy)butane 1,4-di(methylsulfonyloxy)butane |
| NSC code: | 750 |