denileukin diftitox-cxdl
View Patient InformationA cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death.
Synonym: | DAB(389)-interleukin-2 DAB389 interleukin-2 DAB389 interleukin-2 immunotoxin DABIL2 interleukin-2 fusion protein interleukin-2 fusion toxin Ontak |
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US brand name: | Lymphir |
Abbreviation: | DAB389-IL2 DAB389IL-2 DAB389IL2 |
Code name: | LY335348 |
NSC code: | 714744 |