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denileukin diftitox-cxdl

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A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death.
Synonym:DAB(389)-interleukin-2
DAB389 interleukin-2
DAB389 interleukin-2 immunotoxin
DABIL2
interleukin-2 fusion protein
interleukin-2 fusion toxin
Ontak
US brand name:Lymphir
Abbreviation:DAB389-IL2
DAB389IL-2
DAB389IL2
Code name:LY335348
NSC code:714744
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