leucovorin calcium
View Patient InformationAn active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity.
| Synonym: | calcium (6S)-folinate calcium folinate citrovorum factor factor, citrovorum folinate calcium folinic acid folinic acid calcium salt pentahydrate leucovorin |
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| Foreign brand name: | Adinepar Calcifolin Calfolex Calinat Cehafolin Citofolin Citrec Cromatonbic Folinico Dalisol Disintox Divical Ecofol Emovis Flynoken A Folaren Folaxin FOLI-cell Foliben Folidan Folidar Folinac Folinoral Folinvit Foliplus Folix Imo Lederfolat Lederfolin Leucosar Rescufolin Rescuvolin Tonofolin |
| Chemical structure: | 5-formyl tetrahydrofolate 5-formyl-5,6,7,8-tetrahydrofolic acid 5-formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium N-(p-((((6RS)-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1) N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic acid, calcium salt (1:1) N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic acid |
| NSC code: | 3590 |