thiotepa
View Patient InformationA polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.
| Synonym: | thiofosfamide thiophosphamide thiophosphoamide thiophosphoramide triethylene thiophosphoramide triethylenethiophosphoramide |
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| US brand name: | Tepadina Tepylute |
| Abbreviation: | TESPA TSPA |
| Code name: | SH 105 SH-105 SH105 WR 45312 |
| Chemical structure: | 1,1',1''-phosphinothioyldynetrisaziridine 1,1',1"-phosphinothioylidynetrisaziridine N,N',N''-triethylenethiophosphoramide tris(1-aziridinyl)phosphine sulfide |