melphalan hydrochloride
View Patient InformationA bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death.
| US brand name: | Evomela Hepzato |
|---|---|
| Foreign brand name: | Alkerana |
| Chemical structure: | 3-(p-(bis(2-chloroethyl)amino)phenyl)-L-alanine, hydrochloride |
| NSC code: | 241286 |