carmustine
View Patient InformationAn antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily.
| Synonym: | bis-chloronitrosourea bis(chloroethyl) nitrosourea carmustin |
|---|---|
| US brand name: | BiCNU |
| Foreign brand name: | Becenun Carmustinum Nitrourean Nitrumon |
| Abbreviation: | BCNU |
| Code name: | FDA 0345 SK 27702 SRI 1720 WR-139021 |
| Chemical structure: | 1,3-bis(2-chloroethyl)-1-nitrosourea 1,3-bis(beta-chloroethyl)-1-nitrosourea N,N'-bis(2-chloroethyl)-N-nitrosourea |
| IND number: | 969 |
| NSC code: | 409962 |