nelarabine
View Patient InformationAn arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells.
| US brand name: | Arranon |
|---|---|
| Code name: | 506U78 GW506U78 |
| Chemical structure: | 2-amino-6-methoxypurine arabinoside 2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine |
| IND number: | 52611 |
| NSC code: | 686673 |