Skip to main content

Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Temsirolimus

View Patient Information

An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.

Check for active clinical trials using this agent View this agent in the NCI Thesaurus

Synonym:	cell cycle inhibitor 779 Rapamycin Analog rapamycin analog CCI-779
US brand name:	Torisel
Code name:	CCI-779
Chemical structure:	42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin
IND number:	61010
NSC code:	683864

Temsirolimus

Search NCI's Drug Dictionary