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thioguanine

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A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis.
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Synonym:tioguanin
tioguanine
US brand name:Tabloid
Foreign brand name:Lanvis
Abbreviation:6-TG
TG
Code name:BW 5071
Wellcome U3B
WR-1141
X 27
Chemical structure:2-amino 6MP
2-amino-1,7-dihydro-6H-purine-6-thione
2-amino-6-mercaptopurine
2-amino-6-purinethiol
2-aminopurin-6-thiol
2-aminopurine-6-thiol
2-aminopurine-6(1H)-thione
6 mercaptoguanine
6 thioguanine
6-mercapto-2-aminopurine
6-mercaptoguanine
6-thioguanine
6H-purine-6-thione, 2-amino-1,7-dihydro- (9CI)
IND number:7258
936
NSC code:752
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