thioguanine
View Patient InformationA synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis.
| Synonym: | tioguanin tioguanine |
|---|---|
| US brand name: | Tabloid |
| Foreign brand name: | Lanvis |
| Abbreviation: | 6-TG TG |
| Code name: | BW 5071 Wellcome U3B WR-1141 X 27 |
| Chemical structure: | 2-amino 6MP 2-amino-1,7-dihydro-6H-purine-6-thione 2-amino-6-mercaptopurine 2-amino-6-purinethiol 2-aminopurin-6-thiol 2-aminopurine-6-thiol 2-aminopurine-6(1H)-thione 6 mercaptoguanine 6 thioguanine 6-mercapto-2-aminopurine 6-mercaptoguanine 6-thioguanine 6H-purine-6-thione, 2-amino-1,7-dihydro- (9CI) |
| IND number: | 7258 936 |
| NSC code: | 752 |