midostaurin
View Patient InformationA synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.
| Synonym: | N-benzoyl-staurosporine N-benzoylstaurosporine |
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| US brand name: | Rydapt |
| Code name: | CGP 41251 CGP41251 PKC 412 PKC412 |