selumetinib sulfate
View Patient InformationThe sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers.
| Synonym: | selumetinib sulphate |
|---|---|
| US brand name: | Koselugo |
| Code name: | AZD-6244 hydrogen sulfate AZD6244 hydrogen sulfate AZD6244 hydrogen sulphate |
| Chemical structure: | 1H-benzimidazole-6-carboxamide, 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2- hydroxyethoxy)-1-methyl-, sulfate (1:1) 1h-benzimidazole-6-carboxamide,5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2- hydroxyethoxy)-1-methyl-, sulphate (1:1) 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H- benzimidazole-6-carboxamide sulfate 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H- benzimidazole-6-carboxamide sulphate |