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dabrafenib mesylate

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The mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.

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Synonym:	dabrafenib methanesulfonate GSK2118436 methane sulfonate salt GSK2118436B
US brand name:	Tafinlar

dabrafenib mesylate

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