NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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autologous T lymphocytes expressing NY-ESO-1-C259-specific enhanced T cell receptors
Human autologous lymphocytes transduced with a retroviral vector encoding a T cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous T lymphocytes expressing NY-ESO-1-C259-specific enhanced T cell receptors bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for SLLMWITQC, an NY-ESO-1-derived peptide, in a complex with human leukocyte antigen (HLA) A2 peptide. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:autologous T lymphocytes expressing NY-ESO-1-specific, enhanced TCRs
NY-ESO-1/C259T
NY-ESO-1C259T
NY-ESOc259T