melphalan
View Patient InformationA phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
| Synonym: | alanine nitrogen mustard L-phenylalanine mustard L-sarcolysin L-sarcolysin phenylalanine mustard L-sarcolysine phenylalanine mustard phenylalanine nitrogen mustard sarcoclorin |
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| US brand name: | Alkeran |
| Foreign brand name: | Melphalanum Sarkolysin |
| Abbreviation: | L-PAM |
| Code name: | CB-3025 WR-19813 |
| Chemical structure: | 4-[bis(2-chloroethyl)amino]-L-phenylalanine p-di(chloroethyl)amino-L-phenylalanine |
| NSC code: | 241286 8806 |