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FGFR4 inhibitor H3B-6527

An orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis.

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Synonym:	fibroblast growth factor receptor 4 inhibitor H3B-6527
Code name:	H3B 6527 H3B-6527 H3B6527

FGFR4 inhibitor H3B-6527

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