autologous CD4- and CD8-positive truncated CD19-expressing antigen presenting T cells
A preparation of ex vivo expanded, autologous CD4 and CD8 positive antigen presenting T cells (T-APCs), genetically modified with a transgene encoding a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating activity. Upon infusion, autologous CD19t-expressing T-APCs may stimulate the proliferation and activation of preadministered therapeutic CD19-targeted chimeric antigen receptor T cells (CAR-T). This may both improve the persistence of the therapeutic CAR-T cells and prevent relapse in patients with CD19 positive leukemia or lymphoma. CD19 is a B-cell specific cell surface antigen that is expressed in all B-cell lineage malignancies.
| Synonym: | autologous CD19t T-antigen presenting cells autologous CD19t T-APC autologous T-cell antigen presenting cells expressing CD19t autologous T-cell antigen presenting cells expressing truncated CD19 |
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