NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
- allogeneic GM-CSF-secreting breast cancer vaccine SV-BR-1-GM
A vaccine consisting of irradiated allogeneic breast cancer cells, derived from the breast cancer cell line SV-BR-1 that are transfected with the immunostimulant granulocyte-macrophage colony-stimulating factor (GM-CSF; CSF2) gene, with potential immunostimulating and antineoplastic activities. Upon intradermal administration of the allogeneic GM-CSF-secreting breast cancer vaccine SV-BR-1-GM, the genetically-modified cells secrete GM-CSF. This potentiates a tumor-specific cytotoxic T-lymphocyte (CTL) immune response against breast cancer cells. Check for active clinical trials using this agent. (NCI Thesaurus)
Synonym: GM-CSF gene-transfected breast cancer vaccine SV-BR-1-GM
SV-BR-1 breast cancer cell line vaccine
SV-BR1-GM breast cancer vaccine
US brand name: Bria-IMT