NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

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CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes
Autologous T lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR lentiviral vector-transduced autologous T lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:autologous anti-CD33 CAR-T cells
autologous anti-CD33 chimeric antigen receptor T cells
autologous CD33-CAR-T cells