autologous mesothelin-specific CAR-T cells expressing anti-PD-1/CTLA-4 antibodies
A preparation of autologous, engineered T lymphocytes that express both a second-generation chimeric antigen receptor (CAR) specific for the human gastric carcinoma-associated antigen MG7, and the co-stimulatory molecule 4-1BB (CD137), with potential antineoplastic activity. Upon intratumoral injection, the autologous anti-MG7-CAR T lymphocytes target and attach to cancer cells expressing MG7. This induces selective toxicity in and causes lysis of MG7-expressing tumor cells. MG7, a glycosylated protein sequence from the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA), plays a key role in the development of certain tumor cell types. 4-1BB enhances T-cell activation and signaling after recognition of MG7.
| Synonym: | autologous anti-CTLA-4/PD-1 antibodies-expressing meso-CAR-T cells autologous anti-CTLA-4/PD-1 antibodies-expressing mesothelin-targeted CAR-T cells autologous anti-MG7 CAR-T cells autologous anti-MG7-CAR T lymphocytes autologous CTLA-4 and PD-1 antibodies expressing mesothelin-CAR-T cells autologous CTLA4/PD-1-targeting antibodies-expressing mesothelin-CAR-T cells autologous MG7-CART autologous MG7-CART cells MG7-targeted chimeric antigen receptor T cells |
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